CUPRENE Facial Serum — matte black box and frosted glass bottle with copper hardware
The Serum · MMXXVI

The Serum.
Powered by billions of exosomes,
growth factors, and peptides.

Volume30 ml · 1.0 fl oz
ProvenancecGMP-certified · San Diego
Designed forThe 14 signs of aging
Discover the Serum Read the science →
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Our belief

The body already knows how
to heal itself.

For two decades, our research collaborators have studied the language cells use to repair, restore, and renew. The result is a single serum — powered by billions of human and plant stem cell–derived exosomes, growth factors, and peptides. These are the biosignaling messengers your skin uses to communicate, concentrated into a single weightless, fast-absorbing formula.

The science

Healing molecules,
in a bottle.

Age-related decline in the skin begins as an inflammatory process. Stem cells respond by releasing Adult Human Stem Cell–Derived Molecules — a cascade of growth factors, anti-inflammatory cytokines, exosomes, peptides, and collagens. These are the same signals your own tissue uses to repair itself.

The serum contains no cells — only the biosignaling molecules cells release. Rather than masking the signs of aging, it improves cellular communication and tissue regeneration. It is what makes the formula both remarkably effective and remarkably tolerable.

Macro of a golden amber serum droplet resting on luminous skin
01

Stimulate

Collagen synthesis — for firmness and structure.

02

Reduce

Oxidative stress at the cellular level.

03

Improve

Microcirculation, restoring luminosity.

04

Support

Tissue repair after stress or procedure.

05

Modulate

Inflammation, calming reactive skin.

Manufacturing

Cultured, stimulated,
and captured.

Stem cells are cultivated and stimulated in a controlled laboratory to release healing molecules. The majority of the therapeutic benefit of stem cells is carried in these Adult Human Stem Cell–Derived Molecules (AHSDM) — not in the cells themselves.

01

Cell-free by design

The bioactive complex is composed only of AHSDM — no cells, no DNA. Just the signaling molecules that carry up to 80% of a stem cell's healing capacity.

02

Multi-source biology

AHSDM is drawn from two or more stem-cell and progenitor types — a broader signaling profile than any single-source formulation on the market.

03

Rapidly scalable

Production of AHSDM is easily and rapidly scaled by a seasoned technology team — capable of meeting global demand without compromising integrity.

04

San Diego biotech

Located in San Diego for unmatched access to biotech talent, a research-grade facility, and the regulatory infrastructure of California's life-sciences corridor.

05

cGMP for FDA scope

Cosmetic production operates in a non-FDA facility as regulations permit. Any FDA-approved product line will be produced in a fully cGMP-certified facility.

06

Focused vertical integration

AHSDM is produced in-house; all other production is outsourced to specialist partners — keeping the bioactive complex under one roof, and everything else at scale.

The fluid behind the formula

Human stem cell
biotechnology.

When human mesenchymal stem cells are cultivated in a controlled laboratory, they secrete a sophisticated network of signaling molecules into the surrounding nutrient-rich fluid. Purified, cell-free, and DNA-free, this biotechnology is the foundation of the serum.

01

Exosomes

Nanoscale vesicles carrying genetic instructions and proteins directly into skin cells.

02

Growth factors

Specialised proteins that stimulate collagen, cellular turnover, and tissue repair.

03

Cytokines

Signals that regulate inflammation and support a healthy skin barrier.

04

Peptides

Short amino-acid chains associated with firmness and elasticity.

The principle

As skin ages, cellular communication becomes less efficient. This biotechnology helps restore that dialogue — a coordinated network of regenerative signals delivered with every drop.

The renewal cycle

Visible results in
approximately four weeks.

Healthy adult skin renews every 28 to 35 days. Rather than fighting that rhythm, the serum was designed to complement it — supporting one complete renewal cycle so each new layer looks and feels its best.

  1. Week 1

    Hydration & comfort.

    Skin feels more hydrated and cushioned. Makeup applies more evenly.

  2. Week 2

    Suppleness returns.

    A subtle improvement in glow and suppleness. Less dullness, less fatigue.

  3. Week 3

    Texture refines.

    Smoother, more refined texture. Fine lines soften, tone appears more even.

  4. Week 4

    The turning point.

    First full renewal cycle completes — radiance, smoothness, and plumpness.

A realistic benchmark

Four weeks is a natural benchmark based on how healthy skin behaves — not a guarantee. Diet, sleep, climate, and consistency all shape what appears in the mirror. The serum performs best inside a thoughtful ritual.

The buyer's guide

Not every stem-cell
serum is the same.

The phrase “stem-cell serum” can be misleading — two products may share the description yet deliver entirely different technologies. Five criteria separate a serious formula from marketing.

  1. 01

    Source of the stem cells

    Human-derived technology — specifically hADSCs, biocompatible with skin. Plant-cell claims are a different category.

    CUPRENE

    Human-derived stem cells.

  2. 02

    Biotechnology, not live cells

    The purified signaling molecules cells release — cell-free, DNA-free. “Live stem cells” claims are misleading.

    CUPRENE

    Delivers advanced biotechnology.

  3. 03

    Independent clinical testing

    Look for third-party study data — not brand-only claims.

    CUPRENE

    Evaluated with 40 women, ages 35–80.

  4. 04

    A clean, considered formula

    Advanced biotechnology should not require harsh additives.

    CUPRENE

    cGMP-certified. Fragrance, sulfate, silicone free.

  5. 05

    Complementary actives

    Multi-molecular-weight hyaluronic acid and targeted peptide complexes reinforce cellular signals.

    CUPRENE

    Media paired with HA and peptides.

What it does

Fourteen signs
of aging. One serum.

Designed as a foundational step for skin that looks lifted, luminous, and visibly transformed. Consistent use improves elasticity, smooths fine lines, evens tone, and reduces the appearance of inflammation. Ideal for aging, stressed, or post-procedure skin.

The pillars

  • —Lines, wrinkles, saggingVisibly softened.
  • —Collagen synthesisEncouraged and supported.
  • —Skin barrierBolstered and strengthened.
  • —Suppleness & radianceReactivated from within.

The fourteen

  1. 01Fine lines
  2. 02Deep wrinkles
  3. 03Loss of firmness
  4. 04Loss of elasticity
  5. 05Uneven tone
  6. 06Blotchiness
  7. 07Hyperpigmentation
  8. 08Dullness
  9. 09Enlarged pores
  10. 10Rough texture
  11. 11Dryness
  12. 12Sensitivity
  13. 13Redness
  14. 14Post-procedure recovery

After treatment

Professional-grade. Ideal for aging, stressed, or post-procedure skin — a foundational step for a healthier, more youthful-looking complexion.

Woman applying CUPRENE serum from the frosted glass and copper bottle in soft golden light

The ritual

Three drops.
Twice daily.

A quiet ritual, unhurried. Warm three drops between the fingertips. Press — never rub — into cleansed skin, morning and night. Follow with moisturiser.

  1. ICleanse with your usual gentle cleanser.
  2. IIWarm three drops between the fingertips.
  3. IIIPress into cheeks, jaw, neck, and décolleté.
  4. IVWait sixty seconds, then follow with moisturiser.

A note on patience

The skin renews on its own timeline. Give it eight weeks — and it will show you what it remembers.

Inside the bottle

Simple, and
beautifully so.

Sixteen refined ingredients. Nothing more than the skin needs, nothing less than it deserves.

  • —Exosomes & AHSDMHuman stem cell–derived messengers.
  • —Plant stem-cell activesBotanical exosomes for resilience.
  • —Growth factors & peptidesFor collagen, firmness, tone.
  • —Hyaluronic acidWater, held where the skin needs it.
  • —Bellis perennis & Kakadu plumBotanical brightness. Vitamin C.

Free of

DMDM hydantoin Sulfates Silicone Synthetic fragrance Animal testing
Unboxing flat-lay of the CUPRENE box, foam insert tray, bottle, and welcome card

Comparative study

Measured against
five leading serums.

A clinician-supervised comparative study was carried out on AHSDM formulations alongside five commercially available state-of-the-art products. Assessments across eight standard factors demonstrated the AHSDM cream was well tolerated, non-comedogenic, and outperformed every comparison on every measure.

Efficacy delta

+30% or better

On each of eight standard clinical parameters, versus five state-of-the-art competitors.

Volunteer perception

Brighter. Hydrated. Fewer wrinkles.

Healthy volunteers reported the serum made their skin look brighter, felt more hydrated, and reduced the appearance of wrinkles. Nearly all expressed eager willingness to continue use.

A separate 40-subject clinical study (ages 35 – 80, with fine or deep facial wrinkles, barely-visible dark areas, and coarse lower eyelids) confirmed the tolerability and efficacy at the periorbital area — the most delicate skin on the face.

Head-to-head analysis

CUPRENE vs.
other leading brands.

Category-standard topical growth-factor serums work — the peer-reviewed literature supports their efficacy. But nearly all of them are fibroblast-derived. CUPRENE is stem cell-derived. Same category. Different biology. Here is exactly how the two approaches compare.

—
Other brands
CUPRENE
Active source
Fibroblast conditioned media signaling molecules from cultured skin cells
Adult human stem cell-derived molecules (AHSDM) upstream of fibroblasts
Position in cascade
Downstream signals a fibroblast releases when it is instructed
Upstream signals that instruct fibroblasts
Owner / origin
Beauty divisions of large pharmaceutical or cosmetic groups
Backed by two decades of stem cell research from a San Diego institute
Peer-reviewed evidence
Company-sponsored expert-graded split-face studies independent detail often limited
Published in Case Reports in Dermatological Medicine +31% vs. 5 leading serums at 6 weeks
Tolerance
Generally well tolerated may include dairy or fragrance allergens
100% tolerated 40-subject clinical study, ages 35–80
Ingredient count
Typically 30–40+ ingredients often include silicones, PEG derivatives, dairy proteins, penetration enhancers
17 ingredients no silicones, no PEG, no dairy allergens
Manufacturing
Rarely publicly specified
cGMP-certified San Diego, ISO 22716:2007
Regulatory posture
Cosmetic. Some brands have faced prior consumer-safety litigation.
Cosmetic. MoCRA-compliant. Research partner has prior FDA Expanded Access + IND experience.
Price
$185–$385 / 30 ml category range
$475 / 30 ml retail — $399 for first 100 Founders locked for life

Both approaches work. Only one is upstream.

This is not a claim that fibroblast-derived formulations don’t work — the peer-reviewed literature (Wu & Goldman, J Clin Aesthet Dermatol 2017, PMID 28670356) demonstrated efficacy for both source biologies. The choice is between the category-standard fibroblast approach or the upstream adult stem cell approach from the research institute that publishes its own peer-reviewed work.

Download the 10-page comparison PDF

Quiet numbers

What the study
found.

+31%

better than five leading serums

across eight standard measures

100%

tolerated the serum well

no allergic responses

100%

chose to continue at six weeks

in a supervised study

0.05%

return rate over 2,000 units

and near-zero complaints

From the study

"The efficacy and excellent tolerability of the delicate peri-orbital skin area explain why nearly every subject intended to continue use."

Clinical case series

Documented cases from the source institute.

Four documented AHSDM case studies from the San Diego stem cell research institute whose work underlies the CUPRENE formulation. Sequential clinical photography under standardized conditions. Full case files available in the Clinical Evidence dossier.

Clinical Case 01 — Wrinkle reduction with topical AHSDM at baseline, 8 weeks, 6 months
Case 01 · Wrinkles Wrinkle reduction Facial · 6 months
Clinical Case 02 — Accelerated soft-tissue wound closure at baseline, 36 hours, 4 weeks
Case 02 · Wound healing Accelerated wound closure Soft-tissue · 4 weeks
Clinical Case 03 — Inflammation resolution in psoriasis vulgaris at baseline and 6 months
Case 03 · Psoriasis vulgaris Inflammation resolution Psoriatic plaques · 6 months
Clinical Case 04 — Follicular regeneration at baseline, 8 weeks, 12 weeks
Case 04 · Hair regrowth Follicular regeneration Scalp · 12 weeks

Case studies reflect published and documented clinical work by our research partners using AHSDM protocols. Some cases used delivery methods (direct scalp infusion, IV administration) beyond the topical cosmetic serum. Individual results vary. Referenced in the Clinical Evidence dossier.

Evolution of stem-cell therapeutics

A new generation
of restorative science.

First generation

Amniotic tissue, bone-marrow transplant, and PRP — largely autologous.

Second generation

Adult human stem cells and induced pluripotent stem cells — autologous or allogeneic.

Next generation

Adult Human Stem Cell–Derived Molecules (AHSDM) in combination with second-generation methods. Developed by our San Diego research partner.

Up to 80% of the healing capacity of stem cells is carried by these signaling molecules alone — no cells, only their communication.

Chief scientist

Dr. Anand
Srivastava.

M.S., Ph.D. — Chairman, Founder, and Chief Scientific Officer of our research partner institute

A leading authority in stem-cell science, documented across dozens of peer-reviewed publications and two decades of translational research.

Previous FDA collaboration on Expanded Access for Compassionate Use in COVID-19 stem-cell therapy and Type 2 Diabetes IND approval — a foundation of scientific credibility rare in a beauty formulation.

University affiliations

  • UC San Diego
  • UC Irvine
  • UC Los Angeles
  • Salk Institute
  • Sanford Burnham Prebys

Areas of expertise

  • Stem-cell biology
  • Protein biochemistry
  • Molecular biology
  • Immunology
  • In utero transplantation
  • Tissue targeting & gene therapy
  • Clinical research

Full disclosure

Every ingredient.
Nothing hidden.

The bioactive complex

Adult Human Stem Cell–Derived Molecules (AHSDM). Cell-free, DNA-free, produced by cultivating human mesenchymal cells in a controlled cGMP-certified laboratory.

INCI: Human Fibroblast Conditioned Media · Human Stem Cell Conditioned Media

Full ingredients

Aqua · Potassium sorbate · Bellis perennis flower extract · Propanediol · Sodium benzoate · Citric acid · Sodium gluconate · Gluconic acid · Tartaric acid · Glycerin · Terminalia ferdinandiana fruit extract · Glyceryl glucoside · Hyaluronic acid · Xanthan gum · Lactic acid · Pentylene glycol

< 1%

Lactic acid content

1%

Total preservatives (lactic, propanediol, citric, tartaric, gluconic acids)

0

DMDM hydantoin, sulfates, silicones

Compliance

Regulatory alignment,
on both sides of the Atlantic.

Extensive due diligence — aligned with the US FDA, European Commission, and the Personal Care Products Council (PCPC).

United States

  • FD&C Act §201(i) — cosmetic definition compliant
  • CFR Title 21 §700.11 & §700.13 — compliant
  • FDA Form 2511 — Cosmetic Establishment Registration (in process)
  • FDA Form 2512 — Cosmetic Ingredient Statement (in process)
  • CIR-reviewed ingredients across the formulation

European Union

  • CPNP (Cosmetic Product Notification Portal) — in process
  • Regulation (EU) No. 655/2013 — claim criteria observed
  • Full technical dossier and safety assessment on file
  • SCCS-reviewed ingredients across the formulation

Our research partner maintains established links with the FDA through prior collaboration on Expanded Access for Compassionate Use in COVID-19 stem-cell therapy and Type 2 Diabetes IND approval — foundations that expedite regulatory processing for BAM registration.

Read the full record

The complete
proof.

Two documents. One for you, one for your physician. Both are the full story of what CUPRENE is, how it was tested, and what it does.

Beauty Dossier 8 pages · Consumer

The proof.

A visual record of what happens when skin remembers. Four clinical case studies, the science of AHSDM, and the four-week timeline.

Read the dossier

Clinical Evidence 8 pages · Physician reference

Clinical evidence.

Documented outcomes across wrinkles, wound healing, psoriasis, and follicular regeneration. Sequential clinical photography. Contains graphic imagery.

Physician reference

Waitlist

If the first hundred
go before you do.

The Founders' Release is capped at one hundred bottles. On October 1, the standard price becomes $475. When the first 100 are gone, the next allocation opens to the waitlist first. Join the list. Be seen first.

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The serum

The skin you were.
Remembering.

Formulated in San Diego · 30 ml · 1.0 fl oz

Founders' release · First 100 customers only
  • Complimentary worldwide shipping
  • Founders' price locked in for life — never raises
  • Pause, skip, or cancel anytime

First 100 subscribers keep this price forever. Every future delivery stays at $399. Never raises to $475.

While spots last · Complimentary shipping · 30-day guarantee

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